Nilotinib 150 Cap

<ul> <li dir=\"ltr\" style=\"text-align: left;\">Store the product at a temperature of less than 30 ° C</li> <li dir=\"ltr\" style=\"text-align: left;\">Store the product away from moisture and light</li> <li dir=\"ltr\" style=\"text-align: left;\">Keep the product out of the reach of children</li> </ul>

<p dir=\"ltr\" style=\"text-align: left;\"> Contact a poison control center</p>

<ul> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Cardiovascular</strong>: blood pressure, chest pain, irregular heartbeat</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Central nervous system</strong>: fatigue, headache, insomnia, chills, sore mouth, depression, restlessness, migraine, tremor</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Skin</strong>: skin discoloration (yellow), skin rash, dry skin, hair loss, acne, itching, eczema</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Endocrinology and metabolism</strong>: hypothyroidism or hyperthyroidism, increased liver enzymes</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Gastrointestinal</strong>: diarrhea, black stools, anorexia, abdominal pain, vomiting, constipation</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Hematology and oncology</strong>: thrombocytopenia, neutropenia</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Nervous, musculoskeletal</strong>: laxity, hand and foot pain, muscle pain</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Respiratory:</strong> cough, dyspnea, upper respiratory tract infection, speech problems, nosebleeds</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Miscellaneous</strong>: fever, bloody urine, corneal inflammation, gynecomastia, viral infection, flu-like symptoms (1)</li> </ul>

<ul> <li dir=\"ltr\" style=\"text-align: left;\">Concomitant use of nilotinib with the following drugs causes irregular heart rhythms (prolonged QT time): amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin)</li> <li dir=\"ltr\" style=\"text-align: left;\">Drugs that affect the elimination of nilotinib from the body and thus affect the function of nilotinib include: Macrolide antibiotics (such as erythromycin), Azole antifungals (such as itraconazole, ketoconazole), HIV inhibitors ( Such as Saquinavir( , St. John\'s wort, anticonvulsants (such as carbamazepine, phenytoin) (1)</li> <li dir=\"ltr\" style=\"text-align: left;\">Some medicines that may interact with nilotinib include antacids, H2 blockers (e.g., cimetidine, famotidine, ranitidine), proton pump inhibitors (e.g., lansoprazole, omeprazole, pantoprazole)</li> <li dir=\"ltr\" style=\"text-align: left;\"> Do not consume grapefruit juice and its compounds with nilotinib</li> <li dir=\"ltr\" style=\"text-align: left;\">Concomitant use of this drug with imatinib increases the effect of nilotinib (2)</li> </ul>

<p dir=\"ltr\" style=\"text-align: left;\">There are not enough studies in lactating women to determine the risk to the fetus, but due to the possibility of dangerous side effects, the drug is not recommended during breastfeeding</p>

<p style=\"text-align: left;\">    FDA pregnancy category D</p>

<ul> <li dir=\"ltr\" style=\"text-align: left;\">According to the doctor\'s prescription, daily consumption of this medicine is important</li> <li dir=\"ltr\" style=\"text-align: left;\">It is best to take the medicine on an empty stomach (at least 1 hour before or 2 hours after)</li> <li dir=\"ltr\" style=\"text-align: left;\">Tell your doctor if you have liver or pancreatic problems</li> <li dir=\"ltr\" style=\"text-align: left;\">The treating physician should monitor the electrical function of the patient\'s heart before starting the drug and one week after starting it and during treatment on a regular basis (via electrocardiogram test)</li> <li dir=\"ltr\" style=\"text-align: left;\">If you miss a dose, do not double the next dose</li> <li dir=\"ltr\" style=\"text-align: left;\">Before using this drug, it is necessary to measure the serum level of electrolytes, including potassium and magnesium, and check for its deficiency</li> <li dir=\"ltr\" style=\"text-align: left;\">To prevent and control unwanted side effects from the drug, it is best to periodically perform a blood cell count test while taking nilotinib</li> <li dir=\"ltr\" style=\"text-align: left;\">Discontinuation of this drug is necessary before medical and dental examinations and surgery</li> <li dir=\"ltr\" style=\"text-align: left;\">Taking this drug can reduce the level of consciousness, so do not drink alcohol during treatment Avoid activities that require alertness while taking nilotinib</li> <li dir=\"ltr\" style=\"text-align: left;\">Tell your doctor if you are taking herbal supplement (2)</li> </ul>

<ul> <li dir=\"ltr\" style=\"text-align: left;\">People who have symptoms of allergy to this drug</li> <li dir=\"ltr\" style=\"text-align: left;\">People with low levels of potassium and magnesium</li> <li dir=\"ltr\" style=\"text-align: left;\">People with Long QT Syndrome and QT-Internal Prolongation</li> </ul>

<ul> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Treatment of leukemia (chronic bone marrow leukemia ) CML:</strong></li> </ul> <p dir=\"ltr\" style=\"text-align: left;\">Adults: 400 mg twice daily for refractory leukemia</p> <p dir=\"ltr\" style=\"text-align: left;\">              300 mg twice daily for newly diagnosed leukemia</p>

<ul> <li dir=\"ltr\" style=\"text-align: left;\">Treatment of leukemia (chronic bone marrow leukemia ) CM</li> </ul>

<p dir=\"ltr\" style=\"text-align: left;\">Nilotinib by inhibiting various receptors of tyrosine kinases including platelet-derived growth factors (PDGFRα-PDGFRβ), vascular endothelium growth factors (PDGFRβ), vascular endothelium growth factors (PDGFRβ) VEGFR1,2,3, colony stimulating factor type 1 (CSF-1R) and (RET) exert antitumor and anti-   angiogenesis effects (preventing the growth of cancer cells and facilitating cancer cell death)</p>