Sunitinib 12.5 Cap

<ul> <li dir=\"ltr\" style=\"text-align: left;\">Store the product at a temperature of less than 30 ° C</li> <li dir=\"ltr\" style=\"text-align: left;\">Store the product away from moisture and light</li> <li dir=\"ltr\" style=\"text-align: left;\">Keep the product out of the reach of children</li> </ul>

<p dir=\"ltr\" style=\"text-align: left;\">Contact a poison control center.</p>

<ul> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Cardiovascular:</strong> hypertension, peripheral edema, decreased left ventricular ejection fraction, chest pain, edema, venous thromboembolism, heart failure</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Central nervous system:</strong> fatigue, headache, insomnia, chills, sore mouth, depression, dizziness</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Skin:</strong> skin discoloration (yellow), skin rash, hair discoloration, dry skin, hair loss, skin redness, itching</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Endocrinology and Metabolism:</strong> Increased uric acid, decreased serum calcium, decreased serum albumin, decreased serum phosphate, hypothyroidism, increased TSH levels, decreased serum potassium, decreased serum sodium, decreased serum magnesium, weight loss, increased serum calcium, Increased serum sodium, hypoglycemia, hyperglycemia, hyperkalemia</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Gastrointestinal:</strong> diarrhea, inflammation of the mouth, nausea, increased serum lipase, anorexia, abdominal pain, vomiting, indigestion, constipation, decreased appetite, bloating, dry mouth, reflux, tongue pain, hemorrhoids, pancreatitis, Oral plague, dry mucous membranes, gum pain, gingivitis, inflammation of the tongue, vomiting of blood, hematochezia (bloody stools), melena (dark bloody stools), oral mucosal ulcers, tongue ulcers</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Hematology and oncology:</strong> decrease in hemoglobin, lymphocytopenia, bleeding, neutropenia</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Hepatic:</strong> increase in serum aspartate aminotransferase, increase in serum alanine aminotransferase, increase in serum alkaline phosphatase, increase in serum bilirubin, increase in serum indirect bilirubin</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Local:</strong> Local edema</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Nervous, musculoskeletal:</strong> laxity, hand and foot pain, joint pain, back pain, muscle pain</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Renal:</strong> Increased serum creatinine</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Respiratory:</strong> cough, shortness of breath, nosebleeds, nasopharyngitis, sore throat, upper respiratory tract infection, flu-like symptoms, hemoptysis (bloody sputum)</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Miscellaneous:</strong> Fever</li> </ul>

<ul> <li dir=\"ltr\" style=\"text-align: left;\">Sunitinib increases the effect of some drugs, such as: baricitinib, bisphosphonates derivatives, fingolimod, haloperidol, hypoglycemic agents, leflunomide, natalizumab, vaccine (live) and ...</li> <li dir=\"ltr\" style=\"text-align: left;\">Sunitinib reduces the effect of some drugs, such as: smallpox vaccine (live), tertomotide, vaccine, etc.</li> <li dir=\"ltr\" style=\"text-align: left;\">Some drugs reduce the blood level of sunitinib, such as: dabrafenib, deferasirox, echinacea, enzalutamide, erdafitinib, ivosidenib, quinolones, tea plant, tocilizumab, etc.</li> <li dir=\"ltr\" style=\"text-align: left;\">Drinking grapefruit juice reduces the metabolism of sunitinib</li> </ul>

<p dir=\"ltr\" style=\"text-align: left;\">There are not enough studies in lactating women to determine the risk to the fetus, but due to the possibility of dangerous side effects, the drug is not recommended during breastfeeding</p>

<p dir=\"ltr\" style=\"text-align: left;\"> FDA pregnancy category D</p>

<ul> <li dir=\"ltr\" style=\"text-align: left;\">According to the doctor\'s instructions, daily use of this drug is important</li> <li dir=\"ltr\" style=\"text-align: left;\">Be treated with caution due to the dangerous substance of the drug, during transportation and elimination</li> <li dir=\"ltr\" style=\"text-align: left;\">Causes hepatotoxicity, Therefor, liver enzymes should be controlled during treatment.</li> <li dir=\"ltr\" style=\"text-align: left;\">Can reduce the volume of left ventricular exodus (LVEF) to 3 degrees. Use with caution in people with heart disease, bradycardia and electrolyte and blood pressure disorders. Tell your doctor immediately if you see signs of chest pain, fatigue and weakness, irregular breathing, irregular heartbeat and swelling of the hands and feet</li> <li dir=\"ltr\" style=\"text-align: left;\">In people taking CYP3A4 inhibitor drugs such as ketoconazole or its inducers such as rifampin, the sunitinib dose should be corrected by a doctor</li> <li dir=\"ltr\" style=\"text-align: left;\">Wound healing in these patients is delayed, if you notice abnormal bleeding or blood in the urine and feces, tell your doctor immediately</li> <li dir=\"ltr\" style=\"text-align: left;\">Rare cases of proteinuria and nephrotic syndrome have been reported</li> <li dir=\"ltr\" style=\"text-align: left;\">Discontinuation of this drug is necessary before medical and dental tests and surgery</li> <li dir=\"ltr\" style=\"text-align: left;\">Adrenal and thyroid dysfunction may occur and hypoglycemia has been reported in some cases. Tell your doctor immediately if you notice any signs of fatigue, lethargy, palpitations, tremors, or sweating</li> <li dir=\"ltr\" style=\"text-align: left;\">Taking this medicine can cause severe skin reactions or hair and skin discoloration, so if you notice skin lesions, blisters, skin ulcers, fever and chills, tell your doctor immediately</li> <li dir=\"ltr\" style=\"text-align: left;\">Tell your doctor if you are taking herbal and multivitamin supplements</li> </ul>

<ul> <li dir=\"ltr\" style=\"text-align: left;\">People who have symptoms of allergy to this drug</li> </ul>

<ul> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Treatment of gastrointestinal stromal tumor (GIST):</strong></li> </ul> <p dir=\"ltr\" style=\"text-align: left;\">   Adults: Do not take 50 mg once a day for 4 weeks, then 2 weeks. If at the doctor\'s discretion, repeat this treatment process</p> <p dir=\"ltr\" style=\"text-align: left;\">Children: Use and adjustment of doses is done by your doctor</p> <ul dir=\"ltr\" style=\"text-align: left;\"> <li><strong>Advanced Kidney Cancer Treatment (RCC):</strong></li> </ul> <p dir=\"ltr\" style=\"text-align: left;\">   Adults: Do not take 50 mg once a day for 4 weeks, then 2 weeks. If at the doctor\'s discretion, repeat this treatment process</p> <p dir=\"ltr\" style=\"text-align: left;\">Children: Use and adjustment of doses is done by your doctor</p> <ul dir=\"ltr\" style=\"text-align: left;\"> <li><strong>Treatment of advanced, metastasized or non-recurrent neuroendocrine tumors (PNET):</strong></li> </ul> <p dir=\"ltr\" style=\"text-align: left;\">   Adults: 5.37 mg once a day</p> <p dir=\"ltr\" style=\"text-align: left;\">Children: Use and adjustment of doses is done by your doctor</p>

<ul> <li dir=\"ltr\" style=\"text-align: left;\">Treatment of gastrointestinal stromal tumor (GIST):</li> <li dir=\"ltr\" style=\"text-align: left;\">Advanced Kidney Cancer Treatment (RCC)</li> <li dir=\"ltr\" style=\"text-align: left;\">Treatment of advanced, metastasized or non-recurrent neuroendocrine tumors (PNET)</li> </ul>

<p style=\"text-align: left;\">  Sunitinib belongs to the anti-neoplastic maleate drug group and by inhibiting various receptors of tyrosine kinases including platelet-derived growth factors (PDGFRα-PDGFRβ), vascular endothelium growth factors (PDGFRβ), vascular endothelium growth factors (PDGFRβ) VEGFR1,2,3, colony stimulating factor type 1 (CSF-1R) and (RET) exert antitumor and anti-angiogenesis effects (preventing the growth of cancer cells and facilitating cancer cell death)</p>