AVIDIFUMA(Dimethyl Fumarate120 Cap)

<p style=\"text-align: left;\"> Store below 30 ^oC </p> <p style=\"text-align: left;\">  Protect from light and moisture</p> <p style=\"text-align: left;\">  Keep out of rich of children</p>

<p dir=\"ltr\" style=\"text-align: left;\">  Contact a poison control center.</p>

<ul> <li dir=\"ltr\" style=\"text-align: left;\"><a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=10935\">Anaphylaxis</a> and <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=2253\">Angioedema</a></li> <li dir=\"ltr\" style=\"text-align: left;\"><a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=11209\">Progressive Multifocal Leukoencephalopathy</a></li> <li dir=\"ltr\" style=\"text-align: left;\">Lymphopenia</li> <li dir=\"ltr\" style=\"text-align: left;\">Liver Injury</li> <li dir=\"ltr\" style=\"text-align: left;\">Flushing</li> </ul>

<ul> <li dir=\"ltr\" style=\"text-align: left;\"><a href=\"https://www.drugs.com/drug-interactions/adalat-cc-with-dimethyl-fumarate-1717-1076-3464-0.html\"> Nifedipine</a></li> <li dir=\"ltr\" style=\"text-align: left;\"><a href=\"https://www.drugs.com/drug-interactions/ampyra-with-dimethyl-fumarate-3188-14349-3464-0.html\"> Dalfampridine</a></li> <li dir=\"ltr\" style=\"text-align: left;\"><a href=\"https://www.drugs.com/drug-interactions/aspirin-low-strength-with-dimethyl-fumarate-243-3197-3464-0.html\">Aspirin Low Strength (aspirin)</a></li> <li dir=\"ltr\" style=\"text-align: left;\"><a href=\"https://www.drugs.com/drug-interactions/cymbalta-with-dimethyl-fumarate-949-2273-3464-0.html\"> Duloxetine</a></li> <li dir=\"ltr\" style=\"text-align: left;\"><a href=\"https://www.drugs.com/drug-interactions/d3-with-dimethyl-fumarate-646-16191-3464-0.html\">D3 (cholecalciferol)</a></li> <li dir=\"ltr\" style=\"text-align: left;\"><a href=\"https://www.drugs.com/drug-interactions/dimethyl-fumarate-with-euthyrox-3464-0-1463-3511.html\">Levothyroxine</a></li> <li dir=\"ltr\" style=\"text-align: left;\"><a href=\"https://www.drugs.com/drug-interactions/dimethyl-fumarate-with-inderal-3464-0-1956-1266.html\">Propranolol</a></li> <li dir=\"ltr\" style=\"text-align: left;\"><a href=\"https://www.drugs.com/drug-interactions/dimethyl-fumarate-with-magnesiocard-3464-0-1508-10976.html\">Magnesium aspartate</a></li> <li dir=\"ltr\" style=\"text-align: left;\"><a href=\"https://www.drugs.com/drug-interactions/dimethyl-fumarate-with-metoprolol-succinate-er-3464-0-1615-14142.html\">Metoprolol Succinate ER </a></li> <li dir=\"ltr\" style=\"text-align: left;\"><a href=\"https://www.drugs.com/drug-interactions/dimethyl-fumarate-with-metoprolol-tartrate-3464-0-1615-16311.html\">Metoprolol Tartrate </a></li> <li dir=\"ltr\" style=\"text-align: left;\"><a href=\"https://www.drugs.com/drug-interactions/dimethyl-fumarate-with-vitamin-b12-3464-0-754-3756.html\">Vitamin B12 (cyanocobalamin)</a></li> <li dir=\"ltr\" style=\"text-align: left;\"><a href=\"https://www.drugs.com/drug-interactions/dimethyl-fumarate-with-vitamin-c-3464-0-238-3823.html\">Vitamin C (ascorbic acid)</a></li> <li dir=\"ltr\" style=\"text-align: left;\"><a href=\"https://www.drugs.com/drug-interactions/dimethyl-fumarate-with-zyrtec-3464-0-569-286.html\">Cetirizine</a></li> </ul>

<p dir=\"ltr\" style=\"text-align: left;\">It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when is administered to a nursing woman.</p>

<p dir=\"ltr\" style=\"text-align: left;\">FDA pregnancy category C.</p>

<ul> <li dir=\"ltr\" style=\"text-align: left;\">Anaphylaxis and Angioedema: can cause <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=10935\">anaphylaxis</a> and <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=2253\">angioedema</a> after the first dose or at any time during treatment. Signs and symptoms have included difficulty breathing, <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=5919\">urticaria</a>, and swelling of the throat and tongue. Patients should be instructed to discontinue and seek immediate medical care should they experience signs and symptoms of anaphylaxis or angioedema.</li> <li dir=\"ltr\" style=\"text-align: left;\">Progressive Multifocal Leukoencephalopathy</li> <li dir=\"ltr\" style=\"text-align: left;\">Lymphopenia: may decrease lymphocyte counts</li> <li dir=\"ltr\" style=\"text-align: left;\">Liver Injury: The onset has ranged from a few days to several months after initiation of treatment with TECFIDERA. Signs and symptoms of liver injury, including elevation of serum aminotransferases to greater than 5-fold the upper limit of normal and elevation of total bilirubin to greater than 2-fold the upper limit of normal have been observed Elevations of hepatic transaminases. Obtain serum aminotransferase, alkaline phosphatase (ALP), and total bilirubin levels prior to treatment and during treatment, as clinically indicated. Discontinue if clinically significant liver injury is suspected</li> <li dir=\"ltr\" style=\"text-align: left;\"><strong>Flushing: </strong>may cause flushing (e.g., warmth, redness, itching, and/or burning sensation)</li> </ul>

<p style=\"text-align: left;\">   DMF is contraindicated in patients with known hypersensitivity to it or to any of the excipients. Reactions have included anaphylaxis and angioedema.</p>

<ul> <li dir=\"ltr\" style=\"text-align: left;\">The starting dose for DMF is 120 mg twice a day orally</li> <li dir=\"ltr\" style=\"text-align: left;\">After 7 days, the dose should be increased to the maintenance dose of 240 mg twice a day orally</li> <li dir=\"ltr\" style=\"text-align: left;\">Temporary dose reductions to 120 mg twice a day may be considered for individuals who do not tolerate the maintenance dose. Within 4 weeks, the recommended dose of 240 mg twice a day should be resumed</li> <li dir=\"ltr\" style=\"text-align: left;\">The incidence of flushing may be reduced by administration with food</li> </ul>

<p style=\"text-align: left;\">  This drug is indicated for the treatment of patients with relapsing forms of Multiple Sclerosis</p>

<p style=\"text-align: left;\"><em>   In vitro</em> and animal models demonstrate a role for DMF within the Central Nervous System (CNS) in promoting neuronal survival in an Nrf2 pathway-dependent manner. However, the impact of DMF directly within the CNS of MS patients remains largely unknown</p>