Sevelamer 800 Tab

<p style=\"text-align: left;\">Store below 30 ^oC</p> <p style=\"text-align: left;\">Protect from light and moisture.</p> <p style=\"text-align: left;\">Keep out of rich of children.</p>

<p style=\"text-align: left;\"><span style=\"color: #000000;\">Contact a poison control center.</span></p>

<ul> <li style=\"text-align: left;\">Gl: Vomiting- Nausea- Diarrhea- constipation</li> <li style=\"text-align: left;\">Cardiovascular: hypertention</li> <li style=\"text-align: left;\">CNS: headache</li> <li style=\"text-align: left;\">Dermatologics: pruritus.</li> <li style=\"text-align: left;\">Musculoskeletal: arthralgia- pain in limb</li> <li style=\"text-align: left;\">Respiratory: bronchitis- cough</li> </ul>

<ul> <li style=\"text-align: left;\">Administer the drug at least 1 hour before or 3 hours after sevelamer.</li> <li style=\"text-align: left;\">Antiarrythnic and antiseizure medications.</li> <li style=\"text-align: left;\">Ciprofloxacin, Mycophenolate mofetil</li> </ul>

<p style=\"text-align: left;\">No adequate and controlled studies have been conducted in <em>nursing mothers</em><em>. </em>It is not recommended.</p>

<p style=\"text-align: left;\">FDA pregnancy category C.</p> <p style=\"text-align: right;\"><span style=\"color: #000000;\"> </span></p>

<ul> <li style=\"text-align: left;\">Exercise Caution when sevelamer is used in patients with these GI disorders.</li> <li style=\"text-align: left;\">Monitor serum calcium, bicarbonate, and chloride levels.</li> <li style=\"text-align: left;\">Monitor Vitamins D, E, K (clotting factors) And Folic Acid Levels</li> <li style=\"text-align: left;\">The safety and efficacy of sevelamer has not been established in pediatric patients.</li> </ul>

<ul> <li style=\"text-align: left;\">Hypersensivity to sevelamer or any of its constituents.</li> <li style=\"text-align: left;\">Hypophosphatemia or bowel obstruction</li> </ul>

<ul> <li style=\"text-align: left;\">Because the content of sevelamer expand in water, tablets must be swallowed intact and not crushed, chewed, broken in to pices. </li> <li style=\"text-align: left;\">Take sevelamer with meal.</li> <li style=\"text-align: left;\">In patient that not taking a phosphate binder: Based on serum phosphorus level, the recommended starting dosage is 800 to 1600 mg.</li> <li style=\"text-align: left;\">In patients switching from calcium acetate to sevelamer: it needs to adjustment</li> </ul>

<ul> <li style=\"text-align: left;\">Hyperphosphatemia in patient with chronic kidney diseases on hemodialysis.</li> <li style=\"text-align: left;\">Hyperuricemia in patient undergoing hemodialysis.</li> </ul>

<p style=\"text-align: left;\">  It contains multiple amines separated by one carbon from the polymer <a href=\"http://www.rxlist.com/script/main/art.asp?articlekey=10963\">backbone</a>. These amines exist in a protonated form in the intestine and interact with phosphate molecules through ionic and <a href=\"http://www.rxlist.com/script/main/art.asp?articlekey=26767\">hydrogen </a>bonding. By binding phosphate in the dietary tract and decreasing absorption and lowers the phosphate concentration in the serum.</p>