Voriconazole 50 Tab

<p style=\"text-align: left;\">Store below 30 ^oC.     </p> <p style=\"text-align: left;\">  Protect from light and moisture. </p> <p style=\"text-align: left;\">  Keep out of rich of children.</p>

<p style=\"text-align: left;\">Seek emergency medical attention</p> <p style=\"text-align: left;\"><span style=\"color: #000000;\"> </span></p>

<ul> <li style=\"text-align: left;\"><strong>Ocular:</strong></li> <li style=\"text-align: left;\"><strong>Very common:</strong> (10% or more): Abnormal vision (up to 28.1%), visual disturbances/impairment (including altered/enhanced visual perception, blurred vision, chromatopsia, color vision change, photophobia)</li> <li style=\"text-align: left;\"><strong>Common</strong>: (1% to 10%): Photophobia, chromatopsia, <a href=\"https://www.drugs.com/cg/retinal-hemorrhage.html\">retinal hemorrhage</a></li> <li style=\"text-align: left;\">measurements were linked to the administration of voriconazole. Within 14 days</li> </ul> <h3 style=\"text-align: left;\">·        Metabolic</h3> <ul style=\"text-align: left;\"> <li><strong>Very common:</strong> (10% or more): Elevated alkaline phosphatase (up to 22.6%), decreased potassium (up to 16.7%)</li> <li><strong>Common:</strong> (1% to 10%): <a href=\"https://www.drugs.com/cg/hypokalemia.html\">Hypokalemia</a>, <a href=\"https://www.drugs.com/cg/hypoglycemia-in-a-person-with-diabetes.html\">hypoglycemia</a>, <a href=\"https://www.drugs.com/cg/hyponatremia.html\">hyponatremia</a></li> </ul> <h3 style=\"text-align: left;\">·        Renal:</h3> <ul style=\"text-align: left;\"> <li><strong>Very common:</strong> (10% or more): Increased blood creatinine (up to 21.4%)</li> <li><strong>Common:</strong> (1% to 10%): Acute renal failure, abnormal kidney function</li> </ul> <h3 style=\"text-align: left;\">·        Hepatic</h3> <ul style=\"text-align: left;\"> <li><strong>Very common:</strong> (10% or more): Elevated AST (up to 20.3%), elevated total bilirubin (up to 19.4%), elevated ALT (up to 18.9%), abnormal liver function test (including AST, ALT, alkaline phosphatase, GGT, LDH, bilirubin)</li> <li><strong>Common:</strong> (1% to 10%): Increased hepatic enzymes, cholestatic <a href=\"https://www.drugs.com/cg/jaundice.html\">jaundice</a>, bilirubinemia, elevated GGT, elevated LDH, jaundice, hepatitis</li> </ul> <h3 style=\"text-align: left;\">·        Dermatologic</h3> <ul style=\"text-align: left;\"> <li><strong>Very common</strong> (10% or more): Rash (up to 19%)</li> <li><strong>Common</strong> (1% to 10%): <a href=\"https://www.drugs.com/cg/alopecia.html\">Alopecia</a>, exfoliative dermatitis, phototoxic reaction, maculopapular rash, photosensitivity skin reaction, <a href=\"https://www.drugs.com/cg/itchy-skin.html\">pruritus</a>, <a href=\"https://www.drugs.com/cg/itchy-skin.html\">erythema</a>, purpura</li> </ul> <h3 style=\"text-align: left;\">·         Nervous system</h3> <ul style=\"text-align: left;\"> <li><strong>Very common</strong> (10% or more): Headache</li> <li><strong>Common</strong> (1% to 10%): Dizziness, paresthesia, tremor, convulsion, hypertonia, somnolence, <a href=\"https://www.drugs.com/cg/syncope.html\">syncope</a></li> </ul> <h3 style=\"text-align: left;\">·        Other</h3> <ul style=\"text-align: left;\"> <li><strong>Very common:</strong> (10% or more): Fever/pyrexia, peripheral edema</li> <li><strong>Common:</strong> (1% to 10%): Chills, <a href=\"https://www.drugs.com/cg/influenza.html\">influenza</a>-like illness, asthenia, face edema, flu syndrome, chest pain</li> </ul> <h3 style=\"text-align: left;\">Ø Gastrointestinal</h3> <h3 style=\"text-align: left;\">Ø Respiratory</h3> <h3 style=\"text-align: left;\">Ø Cardiovascular</h3> <h3 style=\"text-align: left;\">Ø Hematologic</h3> <h3 style=\"text-align: left;\">Ø Psychiatric</h3> <h3 style=\"text-align: left;\">Ø Musculoskeletal</h3> <h3 style=\"text-align: left;\">Ø Genitourinary</h3>

<ul> <li style=\"text-align: left;\"><a href=\"https://www.drugs.com/drug-interactions/advair-diskus-with-voriconazole-1126-657-2309-0.html\">Advair Diskus (fluticasone / salmeterol)</a>, <a href=\"https://www.drugs.com/drug-interactions/aspirin-low-strength-with-voriconazole-243-3197-2309-0.html\">Aspirin Low Strength (aspirin)</a>, <a href=\"https://www.drugs.com/drug-interactions/clopidogrel-with-voriconazole-705-0-2309-0.html\">Clopidogrel</a>, <a href=\"https://www.drugs.com/drug-interactions/co-trimoxazole-with-voriconazole-2128-12875-2309-0.html\">Co-trimoxazole (sulfamethoxazole / trimethoprim)</a>, <a href=\"https://www.drugs.com/drug-interactions/lasix-with-voriconazole-1146-676-2309-0.html\">Lasix(furosemide)</a>, <a href=\"https://www.drugs.com/drug-interactions/nexium-with-voriconazole-1015-567-2309-0.html\">Nexium (esomeprazole)</a>, <a href=\"https://www.drugs.com/drug-interactions/protonix-with-voriconazole-1790-1152-2309-0.html\">Protonix (pantoprazole)</a>, <a href=\"https://www.drugs.com/drug-interactions/singulair-with-voriconazole-1654-1024-2309-0.html\">Singulair (montelukast)</a>, <a href=\"https://www.drugs.com/drug-interactions/voriconazole-with-warfarin-2309-0-2311-0.html\">warfarin</a>, <a href=\"https://www.drugs.com/drug-interactions/voriconazole-with-zofran-2309-0-1752-1120.html\">Zofran (ondansetron)</a></li> <li style=\"text-align: left;\">This drug in order to decrease plasma concentration should not be used with Rifampin, Carbamazepine</li> <li style=\"text-align: left;\">Coadministration with Ergot should not be occurred</li> </ul>

<p style=\"text-align: left;\">A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother; breastfeeding must be stopped on initiation of therapy</p>

<p style=\"text-align: left;\">US FDA pregnancy category D: There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.</p>

<h4 style=\"text-align: left;\">·         Hepatic Toxicity</h4> <h4 style=\"text-align: left;\">·         Arrhythmias And QT Prolongation(<a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=15599\">Congenital</a> or <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=2118\">acquired</a> QT-prolongation)-</h4> <h4 style=\"text-align: left;\">·         Patients with Renal Impairment</h4> <h4 style=\"text-align: left;\">·         Monitoring of Pancreatic Function-Dermatological Reactions</h4> <ul> <li style=\"text-align: left;\">Concurrent consume with alcohol</li> <li style=\"text-align: left;\"><a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=3215\">Electrolyte</a> disturbances such as hypokalemia, <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=3858\">hypomagnesemia</a> and <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=3855\">hypocalcemia</a> should be corrected prior to initiation of and during Voriconazole therapy</li> </ul>

<ul> <li style=\"text-align: left;\">In case of hypersensitivity to this drug or excipients.</li> </ul> <ul> <li style=\"text-align: left;\">Caution should be used when prescribing this drug to patients with hypersensitivity to other azoles.</li> <li style=\"text-align: left;\">Coadministration of terfenadine, astemizole, cisapride, pimozide or quinidine with Voriconazole is contraindicated because increased plasma concentrations of these drugs can lead to QT prolongation and rare occurrences of torsade de pointes</li> </ul>

<ul> <li style=\"text-align: left;\">Take on an empty stomach.</li> <li style=\"text-align: left;\">Take 1 hour before or 1 hour after meals.</li> <li style=\"text-align: left;\">Keep taking this medicine as you have been told by your doctor or other health care provider, even if you feel well.</li> <li style=\"text-align: left;\">Less than 40 kg: 100 mg orally every 12 hours<br />40 kg or more: 200 mg orally every 12 hours                               </li> </ul>

<ul> <li style=\"text-align: left;\">It is used to treat fungal infections such as:</li> <li style=\"text-align: left;\">Invasive Aspergillosis</li> <li style=\"text-align: left;\">Esophageal Candidiasis</li> </ul>

<p style=\"text-align: left;\">Interferes with fungal cytochrome P450 activity (selectively inhibits 14-alpha-lanosterol demethylation), decreasing ergosterol synthesis (principal sterol in fungal cell membrane) and inhibiting fungal cell membrane formation.</p> <p style=\"text-align: left;\"><strong> </strong></p> <p style=\"text-align: left;\"><span style=\"color: #000000;\"> </span></p>