Fluconazole 100 Tab

<p style=\"text-align: left;\"> Store below 30 ^oC. </p> <p style=\"text-align: left;\">  Protect from light and moisture.</p> <p style=\"text-align: left;\">  Keep out of rich of children.</p>

<p style=\"text-align: left;\">Contact a poison control center.</p> <p style=\"text-align: left;\"><span style=\"color: #000000;\"> </span></p>

<ul> <li style=\"text-align: left;\">Allergic: Rare cases of anaphylaxis has been reported with fluconazole administration.</li> <li style=\"text-align: left;\">Unknown effects: Central nervous system (Seizures);  dermal (exfoliative skin disorders such as Stevens-Johnson syndrome, toxic epidermal necrolysis and alopecia); heamotologic/lymphatic (leukopenia including neutropenia, agranulocytosis and thrombocytopenia); metabolic (hypercholesrterolemia, hypertriglyceridemia; hypokalemia).  Side effects of fluconazole are more pronounced in HIV positive patients.  However, the pattern of the side effects is uniform.  </li> </ul>

<p style=\"text-align: left;\">Rifampicin and cimetidine decrease the effect of fluconazole while hydrochlorothiazides increase its effect.  Fluconazole is known to increase the effect of number of drugs by preventing their metabolism through the inhibition of cytochrome P-450.  This includes benzodiazepines, buspirone, carbamazepine, cisapride, oral contraceptives, statins, corticosteroids, warfarin, tricyclic antidepressants, theophylline, losartan, phenytoin, haloperidol, cyclosporine, alfentanil, tacrolimus, nisoldipine, protease inhibitors, vincristine, zolpidem, zidovudine, toltoridine, sulfonylureas. </p>

<p style=\"text-align: left;\"><span style=\"color: #000000;\">Nursing mothers should not be treated with fluconazole</span></p>

<p style=\"text-align: left;\">FDA pregnancy categorycategory C</p> <p style=\"text-align: left;\"><span style=\"color: #000000;\"> </span></p>

<ul> <li style=\"text-align: left;\">Hepatic injury: In rare cases fluconazole has caused severe hepatic toxicity.</li> <li style=\"text-align: left;\">Dermatologic disorders: In rare cases fluconazole has caused exfoliative skin disorder.</li> </ul> <p style=\"text-align: left;\"><span style=\"color: #000000;\"> </span></p>

<p style=\"text-align: left;\">In case of hypersensitivity to fluconazole or other related family.</p>

<ul> <li style=\"text-align: left;\">Adult:</li> <li style=\"text-align: left;\">Vaginal candidiasis:  oral administration, 150-mg, once daily.</li> <li style=\"text-align: left;\">Oropharyngeal and sophageal candidiasis: First day 200-mg given orally, followed by 100-mg daily for at least 2 weeks to prevent disease relapse.</li> <li style=\"text-align: left;\">Systemic candidiasis: Up to 400-mg per day</li> <li style=\"text-align: left;\">Urinary infections and peritonitis: Between 50-mg to 200-mg per day</li> <li style=\"text-align: left;\">Children: The following table is used to calculate children’s dosage:</li> </ul> <p style=\"text-align: left;\"> </p> <table class=\" alignleft\" width=\"504\"> <tbody> <tr> <td colspan=\"2\" width=\"504\"> <p>Comparison Table for Dosage of Fluconazole in Children vs. Adults</p> </td> </tr> <tr> <td width=\"240\"> <p>Children</p> </td> <td width=\"264\"> <p>Adults</p> </td> </tr> <tr> <td width=\"240\"> <p>3 mg/kg</p> </td> <td width=\"264\"> <p>100 mg</p> </td> </tr> <tr> <td width=\"240\"> <p>6 mg/kg</p> </td> <td width=\"264\"> <p>200 mg</p> </td> </tr> <tr> <td width=\"240\"> <p>12 mg/kg</p> </td> <td width=\"264\"> <p>400 mg</p> </td> </tr> </tbody> </table>

<ul> <li style=\"text-align: left;\">Vaginal candidiasis.</li> <li style=\"text-align: left;\">Oropharyngeal and esophageal candidiasis.</li> <li style=\"text-align: left;\">Cryptococcal meningitis.</li> <li style=\"text-align: left;\">Prophylaxis: Fluconazole is used for the reduction of candidiasis infections in patients undergoing bone marrow transplantation who receive chemotherapy or radiation therapy.</li> </ul>

<p style=\"text-align: left;\">Fluconazole is a selective inhibitor of fungal cytochrome P-450.</p>