Theophylline 300 Cap

<p style=\"text-align: left;\">Store below 30 ^oC. </p> <p style=\"text-align: left;\">  Protect from light and moisture.</p> <p style=\"text-align: left;\">  Keep out of rich of children.</p>

<p style=\"text-align: left;\"><span style=\"color: #000000;\">Contact a poison control center.</span></p>

<ul> <li style=\"text-align: left;\">Adverse reactions associated with theophylline are generally mild when peak serum theophylline concentrations are &lt; 20 mcg/ mL and mainly consist of transient caffeine-like adverse effects such as nausea, vomiting, headache, and insomnia, <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=2985\">diarrhea</a>, irritability, restlessness, fine <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=5502\">skeletal muscle </a>tremors, and transient <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=21221\">diuresis</a>.</li> <li style=\"text-align: left;\">When peak serum theophylline concentrations exceed 20 mcg/mL, however, theophylline produces a wide range of adverse reactions including persistent vomiting,<a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=2628\">cardiac</a> arrhythmias, and <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=4008\">intractable</a> </li> </ul>

<h4 style=\"text-align: left;\">·         . Adenosine</h4> <h4 style=\"text-align: left;\">·         Alcohol</h4> <h4 style=\"text-align: left;\">·         Allopurinol</h4> <h4 style=\"text-align: left;\">·         Aminoglutethimide</h4> <h4 style=\"text-align: left;\">·         Carbamazepine</h4> <h4 style=\"text-align: left;\">·         Cimetidine</h4> <h4 style=\"text-align: left;\">·         Ciprofloxacin</h4> <h4 style=\"text-align: left;\">·         Clarithromycin</h4> <h4 style=\"text-align: left;\">·         Diazepam</h4> <h4 style=\"text-align: left;\">·         Lithium</h4> <h4 style=\"text-align: left;\">·         Lorazepam</h4> <h4 style=\"text-align: left;\">·         Methotrexate (MTX)</h4> <h4 style=\"text-align: left;\">·         Midazolam</h4> <h4 style=\"text-align: left;\">·         Pentoxifylline</h4> <h4 style=\"text-align: left;\">·         Phenobarbital (PB)</h4> <h4 style=\"text-align: left;\">·         Phenytoin</h4> <h4 style=\"text-align: left;\">·         Propafenone</h4> <h4 style=\"text-align: left;\">·         Propranolol</h4> <h4 style=\"text-align: left;\">·         Rifampin</h4> <h4 style=\"text-align: left;\">·         Tacrine</h4> <h4 style=\"text-align: left;\">·         Ticlopidine</h4> <h4 style=\"text-align: left;\">·         Verapamil</h4>

<p style=\"text-align: left;\">It is not recommended. Theophylline is excreted into <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=38691\">breast milk</a> and may cause irritability or other signs of mild toxicity in nursing human infants.</p>

<p style=\"text-align: left;\">FDA pregnancy category C.</p> <p style=\"text-align: left;\"><span style=\"color: #000000;\"> </span></p>

<h4 style=\"text-align: left;\">·         Conditions That Reduce Theophylline Clearance such as:</h4> <h4 style=\"text-align: left;\">Age (Children &lt; 1 year and Elderly  &gt; 60 years), Concurrent Diseases : Acute pulmonary edema ,Congestive heart failure, Cor-pulmonale, Fever for 24 hours or more; or lesser temperature elevations for longer periods, Hypothyroidism, Liver disease; cirrhosis, acute hepatitis, Cessation of Smoking</h4> <h4 style=\"text-align: left;\">·         Theophylline can alter the results of some common laboratory tests. Serum concentrations levels of glucose, uric acid, free fatty acids (cholesterol, HDL), and urinary free cortisol excretion may all be reportedly increased</h4>

<p style=\"text-align: left;\"><span style=\"color: black;\">Theophylline should be used with extreme caution in patients with the following clinical conditions due to the increased risk of<span class=\"apple-converted-space\"> </span><a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=24661\">exacerbation</a><span class=\"apple-converted-space\"> </span>of the concurrent condition: Active<span class=\"apple-converted-space\"> </span><a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=4829\">peptic ulcer</a><span class=\"apple-converted-space\"> </span>disease, <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=11198\">Seizure disorders</a>, <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=2628\">Cardiac</a><span class=\"apple-converted-space\"> </span>arrhythmias (not including Brady arrhythmias</span></p>

<h4 style=\"text-align: left;\">·        Theophylline capsule is intended for patients with relatively continuous or recurring symptoms who have a need to maintain <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=18811\">therapeutic</a> <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=5470\">serum</a> levels of theophylline. It is not intended for patients experiencing an <a href=\"https://www.rxlist.com/script/main/art.asp?articlekey=2133\">acute</a> episode of bronchospasm.</h4> <h4 style=\"text-align: left;\">·        This drug when used as a once-a-day product be administered at night. When two doses per day are prescribed, it is recommended that the second dose be given 10 to 12 hours after the morning dose and before the evening meal.</h4> <h4 style=\"text-align: left;\">·        Patients should be instructed to take this medication at approximately the same time.</h4> <h4 style=\"text-align: left;\">·         not to exceed the prescribed dose.</h4> <h4 style=\"text-align: left;\">·        Taking (theophylline anhydrous capsule) less than one hour before a high-fat-content meal, such milk, 2 fried eggs, hashed brown potatoes, and 2 slices of buttered toast (about 985 calories, including approximately 71 g of fat) may result in a significant increase in peak serum level and in the extent of absorption of theophylline as compared to administration in the fasted state</h4> <h4 style=\"text-align: left;\">·        . Starting Dosage:       for children &lt;45 kg : 12-14 mg/kg/day up to a maximum of 300 mg/day divided Q 24 hrs. And for adult and children &gt;45 kg: 300-400 mg/day1 divided Q 24 hrs.</h4>

<p style=\"text-align: left;\">Theophylline is indicated for the treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases, e.g., emphysema and chronic bronchitis and acute severe asthma.</p>

<p style=\"text-align: left;\">The mechanism of action for theophylline is still being debated. While its bronchoprotective effects are most well-known, theophylline appears to also possess antiinflammatory and immunomodulatory actions. Theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels. In patients with asthma, theophylline reduces airway responsiveness to histamine, methacholine, adenosine, and allergen.</p> <p style=\"text-align: left;\"><span style=\"color: #000000;\"> </span></p>